Regulatory changes associated with the head to trunk developmental transition.

ABSTRACT:

Background

Development of vertebrate embryos is characterized by early formation of the anterior tissues followed by the sequential extension of the axis at their posterior end to build the trunk and tail structures, first by the activity of the primitive streak and then of the tail bud. Embryological, molecular and genetic data indicate that head and trunk development are significantly different, suggesting that the transition into the trunk formation stage involves major changes in regulatory gene networks.

Results

We explored those regulatory changes by generating differential interaction networks and chromatin accessibility profiles from the posterior epiblast region of mouse embryos at embryonic day (E)7.5 and E8.5. We observed changes in various cell processes, includi

SUBMITTER: Duarte P 

PROVIDER: S-EPMC10408190 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature