Identification of robust and generalizable biomarkers for microbiome-based stratification in lifestyle interventions.

ABSTRACT:

Background

A growing body of evidence suggests that the gut microbiota is strongly linked to general human health. Microbiome-directed interventions, such as diet and exercise, are acknowledged as a viable and achievable strategy for preventing disorders and improving human health. However, due to the significant inter-individual diversity of the gut microbiota between subjects, lifestyle recommendations are expected to have distinct and highly variable impacts to the microbiome structure.

Results

Here, through a large-scale meta-analysis including 1448 shotgun metagenomics samples obtained longitudinally from 396 individuals during lifestyle studies, we revealed Bacteroides stercoris, Prevotella copri, and Bacteroides vulgatus as biomarkers of microbiota's resistance to str

SUBMITTER: Chen J 

PROVIDER: S-EPMC10408196 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature