Identifying cellular senescence associated genes involved in the progression of end-stage renal disease as new biomarkers.

ABSTRACT:

Background

Cellular senescence plays an essential role in the development and progression of end-stage renal disease (ESRD). However, the detailed mechanisms phenomenon remains unclear.

Methods

The mRNA expression profiling dataset GSE37171 was taken from the Gene Expression Omnibus (GEO) database. The cell senescence-associated hub genes were selected by applying protein-protein interaction (PPI), followed by correlation analysis, gene interaction analysis, Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. We next explored the relationships of hub genes with miRNAs, TFs, and diseases. The absolute abundance of eight immune cells and two stromal cells were calculated by MCPcount and the correlation of hub genes with these ten

SUBMITTER: Xi YJ 

PROVIDER: S-EPMC10408218 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature