Tracking chromatin state changes using nanoscale photo-proximity labelling.

ABSTRACT: Interactions between biomolecules underlie all cellular processes and ultimately control cell fate. Perturbation of native interactions through mutation, changes in expression levels or external stimuli leads to altered cellular physiology and can result in either disease or therapeutic effects^1,2. Mapping these interactions and determining how they respond to stimulus is the genesis of many drug development efforts, leading to new therapeutic targets and improvements in human health¹. However, in the complex environment of the nucleus, it is challenging to determine protein-protein interactions owing to low abundance, transient or multivalent binding and a lack of technologies that are able to interrogate these interactions without disrupting the protein-binding surf

SUBMITTER: Seath CP 

PROVIDER: S-EPMC10408239 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature