Mind the gap: trajectory of cognitive development in young individuals with sickle cell disease: a cross-sectional study.

ABSTRACT:

Study objectives

Compared to typically developing children and young adults (CYA-TD), those living with Sickle Cell Disease (CYA-SCD) experience more cognitive difficulties, particularly with executive function. Few studies have examined the relative importance of silent cerebral infarction (SCI), haemoglobin and arterial oxygen content on age-related cognitive changes using cross-sectional or longitudinal (developmental trajectory) data. This study presents cohort data from a single timepoint to inform studies with multiple timepoints.

Methods

We compared cross-sectional raw and scaled scores as age-related changes in cognition (trajectories) in CYA-SCD and age-and ethnicity-matched CYA-TD. We also compared cross-sectional age-related changes in cognition (trajectories) in

SUBMITTER: Koelbel M 

PROVIDER: S-EPMC10408298 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature