Shared and distinct biological circuits in effector, memory and exhausted CD8⁺ T cells revealed by temporal single-cell transcriptomics and epigenetics.

ABSTRACT: Naïve CD8⁺ T cells can differentiate into effector (T_eff), memory (T_mem) or exhausted (T_ex) T cells. These developmental pathways are associated with distinct transcriptional and epigenetic changes that endow cells with different functional capacities and therefore therapeutic potential. The molecular circuitry underlying these developmental trajectories and the extent of heterogeneity within T_eff, T_mem and T_ex populations remain poorly understood. Here, we used the lymphocytic choriomeningitis virus model of acute-resolving and chronic infection to address these gaps by applying longitudinal single-cell RNA-sequencing (scRNA-seq) and single-cell assay for transposase-accessible chromatin sequencing (scATAC-seq) a

SUBMITTER: Giles JR 

PROVIDER: S-EPMC10408358 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature