Effects of N-acetyl-L-cysteine polysulfides on periodontitis in a mouse model.

ABSTRACT:

Background

Polysulfides are reported to be involved in various important biological processes. N-acetyl-l-cysteine polysulfide with 2 sulfane sulfur atoms (NAC-S2) regulates diverse toll-like receptor (TLR) signaling pathways. Here, we aimed to determine the role of NAC-S2 in periodontitis and explore the potential mechanism.

Methods

A periodontitis mouse model was established by ligating the subgingival between the first and second molars in wild-type, TLR4^-/- , and Myd88^-/- mice.

Results

NAC-S2 did not affect the proportion of macrophages (CD11b⁺ F4/80⁺ ) or neutrophils (CD11b⁺ GR-1⁺ ) in the bone marrow. Mechanically, lipopolysaccharides (LPS), Zymosan A, or poly I: C induced tumor necrosis factor (T

SUBMITTER: Sun X 

PROVIDER: S-EPMC10408371 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature