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Challenges and prospects of CSF1R targeting for advanced malignancies.

ABSTRACT: CSF1R expression modulates tumor-associated macrophages, making CSF1R blockade an appealing immune-modulating therapeutic target. We evaluated the correlation between CSF1R tumor RNA expression and outcome (pan-cancer setting). RNA expression was ranked as a percentile (0-100) using a standardized internal reference population (735 tumors; 35 histologies). Among 514 patients, there was no difference in survival from biopsy between high and low CSF1R expressors (< 50 percentile versus ≥ 50 percentile rank). There was also no significant difference in median progression-free or overall survival (from treatment) based on CSF1R expression in 21 patients who received CSF1R inhibitors (all p values ≥ 0.08). Concurrent upregulation of ≥ 2 additional immune checkpoint markers (e.g. PD-L1, BTLA, CTLA4, LAG3, TIM3) was observed in all tumor samples with CSF1R expression ≥ 50th percentile. Pending further large prospective studies, patients with high tumor CSF1R expression may need treatment that co-targets the specific immune checkpoint pathways activated in order to impact outcome.

SUBMITTER: Moeller A

PROVIDER: S-EPMC10408490 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Challenges and prospects of CSF1R targeting for advanced malignancies.

Moeller Ann A Kurzrock Razelle R Botta Gregory P GP Adashek Jacob J JJ Patel Hitendra H Lee Suzanna S Pabla Sarabjot S Nesline Mary K MK Conroy Jeffrey J Sicklick Jason K JK Kato Shumei S

American journal of cancer research 20230715 7

CSF1R expression modulates tumor-associated macrophages, making CSF1R blockade an appealing immune-modulating therapeutic target. We evaluated the correlation between CSF1R tumor RNA expression and outcome (pan-cancer setting). RNA expression was ranked as a percentile (0-100) using a standardized internal reference population (735 tumors; 35 histologies). Among 514 patients, there was no difference in survival from biopsy between high and low CSF1R expressors (< 50 percentile versus ≥ 50 percen ...[more]

PMID: 37560003

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Challenges and prospects of CSF1R targeting for advanced malignancies.

Publications

Challenges and prospects of CSF1R targeting for advanced malignancies.

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