Genome-wide screening for circRNAs in epicardial adipose tissue of heart failure patients with preserved ejection fraction.

ABSTRACT:

Objective

Heart failure with preserved ejection fraction (HFpEF) is a complex cardiovascular syndrome. Along with pro-inflammatory and metabolic factors, epicardial adipose tissue (EAT) is believed to play a key role in the pathogenesis of HFpEF. Studies have increasingly shown a critical role of circRNAs in the development of cardiovascular diseases; however, their role in the pathogenetic mechanism of HFpEF is not well characterized. The objective of this study was to investigate the expression profiles of circRNAs in EAT of HFpEF patients.

Methods

Samples of epicardial adipose tissue were obtained from patients with HFpEF (n=5) and patients without heart failure (non-HF; n=5). CircRNA expression profiles were screened using RNA sequencing method. RNA-sequencing results we

SUBMITTER: He S 

PROVIDER: S-EPMC10408519 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature