Down-regulation of Jun induces senescence through destabilizing chromatin in osteoarthritis chondrocytes.

ABSTRACT:

Objective

Osteoarthritis (OA) is the most common degenerative joint disease leading to disability worldwide. Cellular senescence is considered to be a fundamental pathogenic mechanism in the development of OA and has attracted increasing attention. However, regulatory mechanisms underlying chondrocyte senescence in OA remain unclear.

Methods

Bioinformatic methods were used to screen key genes. Immunohistochemistry and the quantitative reverse transcription polymerase chain reaction were used to evaluate gene expression. RNA intervention experiments were performed to explore the functions of key genes.

Results

We used 494 aging-associated genes provided by the Aging Atlas to identify the co-expression modules associated with age and OA. Thirty age-associated differenti

SUBMITTER: Xie T 

PROVIDER: S-EPMC10408544 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature