Network pharmacology of the Yigu Decoction empirical formula on the treatment of knee osteoarthritis.

ABSTRACT:

Objective

To investigate the mechanism of the Yigu Decoction empirical formula in the treatment of knee osteoarthritis (KOA) using network pharmacology and molecular docking methods.

Methods

The active ingredients and targets of Yigu Decoction were screened using the TCMSP database. Relevant targets were predicted using several databases. A "drug-component-target-disease" network was constructed using Cytoscape software. A protein-protein interaction network was constructed using the STRING database. Gene Ontology and Kyoto Encyclopaedia of Genes and Genomes signalling pathways of the target genes were analysed.

Results

We identified 18 components of Rhizoma drynariae (Gusuibu), 23 components of Yinyanghuo (Herba Epimedii Brevicornus), 16 components of Yam, 65

SUBMITTER: Wang J 

PROVIDER: S-EPMC10408545 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature