[The Effect of Short-Term Intermittent Hypoxia Exposure on Mouse Myocardial Oxidative Stress and Cardiac Function].

ABSTRACT:

Objective

To investigate the effect of short-term intermittent hypoxia (IH) on the structure and function of mouse myocardium.

Methods

Thirty male C57BL6/J mice were randomly assigned to two groups, a control (Con) group and an IH group exposed to hypoxic treatment at atmospheric pressure. The IH group received 10% oxygen pretreatment for 8 hours per day on 14 consecutive days, while the Con group was exposed to normoxia environment and all the other treatment the group received were identical to those given to the IH group, The body mass of the mice was monitored daily during the treatment. The exercise tolerance and the cardiac function of isolated heart were assessed at the end of IH exposure. Additionally, analysis was conducted regarding myocardial enzymology, histology

SUBMITTER: Ou W 

PROVIDER: S-EPMC10408848 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature