[Effects of Long-Term Ethanol Consumption on Learning-Memory Functions in Mice and the Mechanisms Involved].

ABSTRACT:

Objective

To investigate the effect of long-term ethanol consumption on learning-memory functions in mice and the mechanisms involved.

Methods

Thirty male C57BL6/J mice were randomly assigned to 3 groups, with 10 mice in each group. The three groups included a control group in which the mice were given water ad libitum for 30 days, a long-term ethanol consumption group, or the EtOH group, in which the mice were given 6% (volume fraction) ethanol ad libitum for 30 days, and a long-term alcoholism group, or the EtOH+G group, in which the mice were given 5% (volume fraction) ethanol ad libitum for 30 days plus intermittent intragastric gavage of 20% ethanol at 3.5 g per kilogram body mass once every three days. After 30 days, the learning-memory functions o

SUBMITTER: Zhou J 

PROVIDER: S-EPMC10408975 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature