[Bioinformatics Analysis of Hub Genes of Diabetic Foot Ulcer and Their Biofunctions].

ABSTRACT:

Objective

To explore the hub genes associated with the pathogenesis and healing of diabetic foot ulcer (DFU) and their biological functions through bioinformatics analysis of transcriptome sequencing data.

Methods

The transcriptome sequencing datasets of DFU were selected from Gene Expression Omnibus (GEO) database, and the data were regrouped and normalized for bioinformatics analysis. The skin transcriptome sequencing datasets of DFU patients were compared with those of normal controls and the transcriptome sequencing datasets of skin from ulcerous wound edge of DFU patients were compared with those of non-ulcerous skin of DFU patients so that differentially expressed genes were identified, pathway enrichment and protein-to-protein interaction (PPI) analyses were performed

SUBMITTER: Xu F 

PROVIDER: S-EPMC10408990 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature