Cognition and education benefits of increased hemoglobin and blood oxygenation in children with sickle cell disease.

ABSTRACT:

Background

Among individuals with sickle cell disease (SCD), decreased hemoglobin is associated with lower oxygen saturation (SpO2) and increased risk of stroke, both of which are associated with lower intelligence quotient (IQ) scores. Thus, increasing hemoglobin and SpO2 in individuals with SCD may increase IQ and educational attainment.

Methods

A cohort simulation model was built to determine academic performance and educational attainment based on cognitive function (measured by IQ) of a pediatric SCD cohort randomly assigned to treatment and control groups. The model contained two key stages: childhood (<10 years) and adolescence (≥10 years). In stage 1, increased hemoglobin and increased SpO2 (assigned to the treatment group) were determinants of higher IQ, prevention

SUBMITTER: MacEwan JP 

PROVIDER: S-EPMC10409269 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature