Synchronous multi-segmental activity between metachronal waves controls locomotion speed in Drosophila larvae.

ABSTRACT: The ability to adjust the speed of locomotion is essential for survival. In limbed animals, the frequency of locomotion is modulated primarily by changing the duration of the stance phase. The underlying neural mechanisms of this selective modulation remain an open question. Here, we report a neural circuit controlling a similarly selective adjustment of locomotion frequency in Drosophila larvae. Drosophila larvae crawl using peristaltic waves of muscle contractions. We find that larvae adjust the frequency of locomotion mostly by varying the time between consecutive contraction waves, reminiscent of limbed locomotion. A specific set of muscles, the lateral transverse (LT) muscles, co-contract in all segments during this phase, the duration of which sets the duration of the i

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10409504 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature