Association Between Telomere Length and Risk of Lung Cancer in an Asian Population: A Mendelian Randomization Study.

ABSTRACT:

Background

Several traditional observational studies and Mendelian randomization (MR) studies have indicated an association between leukocyte telomere length (LTL) and the risk of lung cancer in the European population. However, the results in the Asian population are still unclear. The objective was to reveal the genetic causal association between LTL and the risk of lung cancer in the Asian population.

Methods

We conducted a two-sample MR analysis using summary statistics. Instrumental variables (IVs) were obtained from the genome-wide association studies (GWAS) of LTL (n = 23,096) and lung cancer (n = 212,453) of Asian ancestry. We applied the random-effects inverse-variance weighted (IVW) model as the main method. As well, several other models were performed as complemen

SUBMITTER: Teng Y 

PROVIDER: S-EPMC10409562 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature