Structural-and-dynamical similarity predicts compensatory brain areas driving the post-lesion functional recovery mechanism.

ABSTRACT: The focal lesion alters the excitation-inhibition (E-I) balance and healthy functional connectivity patterns, which may recover over time. One possible mechanism for the brain to counter the insult is global reshaping functional connectivity alterations. However, the operational principles by which this can be achieved remain unknown. We propose a novel equivalence principle based on structural and dynamic similarity analysis to predict whether specific compensatory areas initiate lost E-I regulation after lesion. We hypothesize that similar structural areas (SSAs) and dynamically similar areas (DSAs) corresponding to a lesioned site are the crucial dynamical units to restore lost homeostatic balance within the surviving cortical brain regions. SSAs and DSAs are independent measures, one b

SUBMITTER: Chakraborty P 

PROVIDER: S-EPMC10409568 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature