Genome-wide Analysis of Motor Progression in Parkinson Disease.

ABSTRACT:

Background and objectives

The genetic basis of Parkinson disease (PD) motor progression is largely unknown. Previous studies of the genetics of PD progression have included small cohorts and shown a limited overlap with genetic PD risk factors from case-control studies. Here, we have studied genomic variation associated with PD motor severity and early-stage progression in large longitudinal cohorts to help to define the biology of PD progression and potential new drug targets.

Methods

We performed a GWAS meta-analysis of early PD motor severity and progression up to 3 years from study entry. We used linear mixed-effect models with additive effects, corrected for age at diagnosis, sex, and the first 5 genetic principal components to assess variability in axial, limb, and tot

SUBMITTER: Martinez Carrasco A 

PROVIDER: S-EPMC10409573 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature