KOMPUTE: imputing summary statistics of missing phenotypes in high-throughput model organism data.

ABSTRACT:

Motivation

The International Mouse Phenotyping Consortium (IMPC) is striving to build a comprehensive functional catalog of mammalian protein-coding genes by systematically producing and phenotyping gene-knockout mice for almost every protein-coding gene in the mouse genome and by testing associations between gene loss-of-function and phenotype. To date, the IMPC has identified over 90 000 gene-phenotype associations, but many phenotypes have not yet been measured for each gene, resulting in largely incomplete data; ∼75.6% of association summary statistics are still missing in the latest IMPC summary statistics dataset (IMPC release version 16).

Results

To overcome these challenges, we propose KOMPUTE, a novel method for imputing missing summary statistics in the IMPC datase

SUBMITTER: Warkentin C 

PROVIDER: S-EPMC10409646 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature