Ontology highlight
ABSTRACT:
SUBMITTER: Macesic N
PROVIDER: S-EPMC10409761 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Macesic Nenad N Hawkey Jane J Vezina Ben B Wisniewski Jessica A JA Cottingham Hugh H Blakeway Luke V LV Harshegyi Taylor T Pragastis Katherine K Badoordeen Gnei Zweena GZ Dennison Amanda A Spelman Denis W DW Jenney Adam W J AWJ Peleg Anton Y AY
Nature communications 20230808 1
Infections caused by metallo-beta-lactamase-producing organisms (MBLs) are a global health threat. Our understanding of transmission dynamics and how MBLs establish endemicity remains limited. We analysed two decades of bla<sub>IMP-4</sub> evolution in a hospital using sequence data from 270 clinical and environmental isolates (including 169 completed genomes) and identified the bla<sub>IMP-4</sub> gene across 7 Gram-negative genera, 68 bacterial strains and 7 distinct plasmid types. We showed h ...[more]