Automated analysis of a large-scale paediatric dataset illustrates the interdependent relationship between epilepsy and sleep.

ABSTRACT: Slow waves are an electrophysiological characteristic of non-rapid eye movement sleep and a marker of the restorative function of sleep. In certain pathological conditions, such as different types of epilepsy, slow-wave sleep is affected by epileptiform discharges forming so-called "spike-waves". Previous evidence shows that the overnight change in slope of slow waves during sleep is impaired under these conditions. However, these past studies were performed in a small number of patients, considering only short segments of the recording night. Here, we screened a clinical data set of 39'179 pediatric EEG recordings acquired in the past 25 years (1994-2019) at the University Children's Hospital Zurich and identified 413 recordings of interest. We applied an automated approach based on machi

SUBMITTER: Skorucak J 

PROVIDER: S-EPMC10409812 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature