Adiposity-associated atrial fibrillation: molecular determinants, mechanisms, and clinical significance.

ABSTRACT: Obesity is an important contributing factor to the pathophysiology of atrial fibrillation (AF) and its complications by causing systemic changes, such as altered haemodynamic, increased sympathetic tone, and low-grade chronic inflammatory state. In addition, adipose tissue is a metabolically active organ that comprises various types of fat deposits with discrete composition and localization that show distinct functions. Fatty tissue differentially affects the evolution of AF, with highly secretory active visceral fat surrounding the heart generally having a more potent influence than the rather inert subcutaneous fat. A variety of proinflammatory, profibrotic, and vasoconstrictive mediators are secreted by adipose tissue, particularly originating from cardiac fat, that promote atrial remod

SUBMITTER: Gawalko M 

PROVIDER: S-EPMC10409902 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature