E-cigarette exposure augments murine abdominal aortic aneurysm development: role of Chil1.

ABSTRACT:

Aims

Abdominal aortic aneurysm (AAA) is a common cardiovascular disease with a strong correlation to smoking, although underlying mechanisms have been minimally explored. Electronic cigarettes (e-cigs) have gained recent broad popularity and can deliver nicotine at comparable levels to tobacco cigarettes, but effects on AAA development are unknown.

Methods and results

We evaluated the impact of daily e-cig vaping with nicotine on AAA using two complementary murine models and found that exposure enhanced aneurysm development in both models and genders. E-cigs induced changes in key mediators of AAA development including cytokine chitinase-3-like protein 1 (CHI3L1/Chil1) and its targeting microRNA-24 (miR-24). We show that nicotine triggers inflammatory signalling and reactive

SUBMITTER: Mulorz J 

PROVIDER: S-EPMC10409905 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature