Surface Lin28A expression consistent with cellular stress parallels indicators of senescence.

ABSTRACT:

Aims

Declining cellular functional capacity resulting from stress or ageing is a primary contributor to impairment of myocardial performance. Molecular pathway regulation of biological processes in cardiac interstitial cells (CICs) is pivotal in stress and ageing responses. Altered localization of the RNA-binding protein Lin28A has been reported in response to environmental stress, but the role of Lin28A in response to stress in CICs has not been explored. Surface Lin28A redistribution is indicative of stress response in CIC associated with ageing and senescence.

Methods and results

Localization of Lin28A was assessed by multiple experimental analyses and treatment conditions and correlated to oxidative stress, senescence, and ploidy in adult murine CICs. Surface Lin28A expr

SUBMITTER: Broughton K 

PROVIDER: S-EPMC10409908 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature