Comparative in vivo biodistribution of cells labelled with [⁸⁹Zr]Zr-(oxinate)₄ or [⁸⁹Zr]Zr-DFO-NCS using PET.

ABSTRACT:

Background

In vivo monitoring of cell biodistribution using positron emission tomography (PET) provides a quantitative non-invasive method to further optimize cell therapies and related new developments in the field. Our group has earlier optimized and evaluated the in vitro properties of two radiotracers,[⁸⁹Zr]Zr-(oxinate)₄ and [⁸⁹Zr]Zr-DFO-NCS, for the radiolabelling of different cell types. Here, we performed a microPET study to assess the in vivo biodistribution of cells in rats using these two radiotracers. Human decidual stromal cells (hDSC) and rat macrophages (rMac) were radiolabelled with [⁸⁹Zr]Zr-(oxinate)₄ or [⁸⁹Zr]Zr-DFO-NCS. Rats were intravenously injected with radiolabelled cells, and the in vivo biodi

SUBMITTER: Friberger I 

PROVIDER: S-EPMC10409919 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature