Ephrin-Eph receptor tyrosine kinases for potential therapeutics against hepatic pathologies.

ABSTRACT: Hepatic fibrosis is the common pathological change that occurs due to increased synthesis and accumulation of extracellular matrix components. Chronic insult from hepatotoxicants leads to liver cirrhosis, which if not reversed timely using appropriate therapeutics, liver transplantation remains the only effective therapy. Often the disease further progresses into hepatic carcinoma. Although there is an increased advancement in understanding the pathological phenotypes of the disease, additional knowledge of the novel molecular signaling mechanisms involved in the disease progression would enable the development of efficacious therapeutics. Ephrin-Eph molecules belong to the largest family of receptor tyrosine kinases (RTKs) which are identified to play a crucial role in cellular migratory

SUBMITTER: Mekala S 

PROVIDER: S-EPMC10409970 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature