Angiopoietin-2 is associated with capillary leak and predicts complications after cardiac surgery.

ABSTRACT:

Background

Patients undergoing cardiac surgery are prone to numerous complications. Increased vascular permeability may be associated with morbidity and mortality due to hemodynamic instability, fluid overload, and edema formation. We hypothesized that markers of endothelial injury and inflammation are associated with capillary leak, ultimately increasing the risk of postoperative complications.

Methods

In this prospective, observational, multidisciplinary cohort study at our tertiary academic medical center, we recruited 405 cardiac surgery patients. Patients were assessed daily using body impedance electrical analysis, ultrasound, sublingual intravital microscopy, and analysis of serum biomarkers. Multivariable models, as well as machine learning, were used to study the as

SUBMITTER: Wollborn J 

PROVIDER: S-EPMC10409979 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature