The D₃ -creatine dilution method non-invasively measures muscle mass in mice.

ABSTRACT: Developing accurate methods to quantify age-related muscle loss (sarcopenia) could greatly accelerate development of therapies to treat muscle loss in the elderly, as current methods are inaccurate or expensive. The current gold standard method for quantifying sarcopenia is dual-energy X-ray absorptiometry (DXA) but does not measure muscle directly-it is a composite measure quantifying "lean mass" (muscle) excluding fat and bone. In humans, DXA overestimates muscle mass, which has led to erroneous conclusions about the importance of skeletal muscle in human health and disease. In animal models, DXA is a popular method for measuring lean mass. However, instrumentation is expensive and is potentially limited by anesthesia concerns. Recently, the D₃ -creatine (D₃ Cr) dil

SUBMITTER: Wimer L 

PROVIDER: S-EPMC10410001 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature