Endothelial cell telomere dysfunction induces senescence and results in vascular and metabolic impairments.

ABSTRACT: In advanced age, increases in oxidative stress and inflammation impair endothelial function, which contributes to the development of cardiovascular disease (CVD). One plausible source of this oxidative stress and inflammation is an increase in the abundance of senescent endothelial cells. Cellular senescence is a cell cycle arrest that occurs in response to various damaging stimuli. In the present study, we tested the hypothesis that advanced age results in endothelial cell telomere dysfunction that induces senescence. In both human and mouse endothelial cells, advanced age resulted in an increased abundance of dysfunctional telomeres, characterized by activation of DNA damage signaling at telomeric DNA. To test whether this results in senescence, we selectively reduced the telomere shelte

SUBMITTER: Bloom SI 

PROVIDER: S-EPMC10410008 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature