Aberrant expression of histone deacetylase 8 in endometriosis and its potential as a therapeutic target.

ABSTRACT:

Purpose

To screen Zn²⁺-dependent histone deacetylase (HDAC) 1-11 in endometriotic cells and then evaluated the HDACs identified from the screening in ovarian endometrioma (OE) and deep endometriotic (DE) lesions, and to evaluate the therapeutic potential of HDAC8 inhibition in mice.

Methods

Quantification of gene and protein expression levels of HDAC1-11 in endometriotic cells stimulated by TGF-β1, and immunohistochemistry analysis of Class I HDACs and HDAC6 in OE/DE lesion samples. The therapeutic potential of HDAC8 inhibition was evaluated by a mouse model of deep endometriosis.

Results

The screening identified Class I HDACs and HDAC6 as targets of interest. Immunohistochemistry analysis found a significant elevation in HDAC8 immunostaining in both OE and

SUBMITTER: Zheng H 

PROVIDER: S-EPMC10410010 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature