Age- and sex-dependent alterations in primary somatosensory cortex neuronal calcium network dynamics during locomotion.

ABSTRACT: Over the past 30 years, the calcium (Ca²⁺ ) hypothesis of brain aging has provided clear evidence that hippocampal neuronal Ca²⁺ dysregulation is a key biomarker of aging. Age-dependent Ca²⁺ -mediated changes in intrinsic excitability, synaptic plasticity, and activity have helped identify some of the mechanisms engaged in memory and cognitive decline based on work done mostly at the single-cell level and in the slice preparation. Recently, our lab identified age- and Ca²⁺ -related neuronal network dysregulation in the cortex of the anesthetized animal. Still, investigations in the awake animal are needed to test the generalizability of the Ca²⁺ hypothesis of brain aging. Here, we used in vigilo two-photon imaging in ambulating mice, t

SUBMITTER: Case SL 

PROVIDER: S-EPMC10410056 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature