In vitro and in vivo effects of Pelargonium sidoides DC. root extract EPs^® 7630 and selected constituents against SARS-CoV-2 B.1, Delta AY.4/AY.117 and Omicron BA.2.

ABSTRACT: The occurrence of immune-evasive SARS-CoV-2 strains emphasizes the importance to search for broad-acting antiviral compounds. Our previous in vitro study showed that Pelargonium sidoides DC. root extract EPs^® 7630 has combined antiviral and immunomodulatory properties in SARS-CoV-2-infected human lung cells. Here we assessed in vivo effects of EPs^® 7630 in SARS-CoV-2-infected hamsters, and investigated properties of EPs^® 7630 and its functionally relevant constituents in context of phenotypically distinct SARS-CoV-2 variants. We show that EPs^® 7630 reduced viral load early in the course of infection and displayed significant immunomodulatory properties positively modulating disease progression in hamsters. In addition, we fin

SUBMITTER: Emanuel J 

PROVIDER: S-EPMC10410074 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature