Differential effects of two-hit models of acute and ventilator-induced lung injury on lung structure, function, and inflammation.

ABSTRACT: Acute respiratory distress syndrome (ARDS) and acute lung injury have a diverse spectrum of causative factors including sepsis, aspiration of gastric contents, and near drowning. Clinical management of severe lung injury typically includes mechanical ventilation to maintain gas exchange which can lead to ventilator-induced lung injury (VILI). The cause of respiratory failure is acknowledged to affect the degree of lung inflammation, changes in lung structure, and the mechanical function of the injured lung. However, these differential effects of injury and the role of etiology in the structure-function relationship are not fully understood. To address this knowledge gap we caused lung injury with intratracheal hydrochloric acid (HCL) or endotoxin (LPS) 2 days prior to ventilation or with a

SUBMITTER: Bilodeaux J 

PROVIDER: S-EPMC10410077 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature