Integrative multi-omics analyses unravel the immunological implication and prognostic significance of CXCL12 in breast cancer.

ABSTRACT:

Background

CXCL12 is a vital factor in physiological and pathological processes, by inducing migration of multiple cells. We aimed to comprehensively detect the role of CXCL12 in breast cancer, and explore novel CXCL12-related biomarkers through integrative multi-omics analyses to build a powerful prognostic model for breast cancer patients.

Methods

Immunohistochemistry analysis of the tissue microarray was performed to evaluate the correlation between CXCL12 expression levels and breast cancer patient outcomes. Combined single-nucleus and spatial transcriptomics data was used to uncover the expression distribution of CXCL12 in breast cancer microenvironment. CXCL12-related genes were identified by WGCNA analysis. Univariate Cox and LASSO regression analyses were then conduc

SUBMITTER: Gao ZJ 

PROVIDER: S-EPMC10410148 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature