Association between uric acid and risk of venous thromboembolism in East Asian populations: a cohort and Mendelian randomization study.

ABSTRACT:

Background

Serum uric acid (SUA) levels have been associated with an increased risk and recurrence of venous thromboembolism (VTE) in European populations, but the potential causal relationship remains unclear. Large-scale studies on the association between SUA and VTE in East Asian populations are lacking, despite the high prevalence of hyperuricemia in this region. To address this, we conducted a cohort analysis and a two-sample Mendelian randomization (MR) study in East Asian populations.

Methods

We collected data on VTE patients from the China Pulmonary Thromboembolism Registry Study (CURES) and compared them to controls obtained from the China Health and Retirement Longitudinal Survey (CHARLS). Propensity score matching (PSM) and cubic-spline models were applied to asse

SUBMITTER: Weng H 

PROVIDER: S-EPMC10410163 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature