Tumor-Derived Extracellular Vesicles: Multifunctional Entities in the Tumor Microenvironment.

ABSTRACT: Tumor cells release extracellular vesicles (EVs) that can function as mediators of intercellular communication in the tumor microenvironment. EVs contain a host of bioactive cargo, including membrane, cytosolic, and nuclear proteins, in addition to noncoding RNAs, other RNA types, and double-stranded DNA fragments. These shed vesicles may deposit paracrine information and can also be taken up by stromal cells, causing the recipient cells to undergo phenotypic changes that profoundly impact diverse facets of cancer progression. For example, this unique form of cellular cross talk helps condition the premetastatic niche, facilitates evasion of the immune response, and promotes invasive and metastatic activity. These findings, coupled with those demonstrating that the number and content of EV

SUBMITTER: Clancy JW 

PROVIDER: S-EPMC10410237 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature