OSA Is Associated With the Human Gut Microbiota Composition and Functional Potential in the Population-Based Swedish CardioPulmonary bioImage Study.

ABSTRACT:

Background

OSA is a common sleep-breathing disorder linked to increased risk of cardiovascular disease. Intermittent upper airway obstruction and hypoxia, hallmarks of OSA, have been shown in animal models to induce substantial changes to the gut microbiota composition, and subsequent transplantation of fecal matter to other animals induced changes in BP and glucose metabolism.

Research question

Does OSA in adults associate with the composition and functional potential of the human gut microbiota?

Study design and methods

We used respiratory polygraphy data from up to 3,570 individuals 50 to 64 years of age from the population-based Swedish Cardiopulmonary bioimage Study combined with deep shotgun metagenomics of fecal samples to identify cross-sectional associations

SUBMITTER: Baldanzi G 

PROVIDER: S-EPMC10410248 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature