Establishment of a mathematical prediction model for voriconazole stable maintenance dose: a prospective study.

ABSTRACT:

Background

In patients with invasive fungal infection (IFI), the steady-state serum trough concentration (C _min) of voriconazole (VCZ) is highly variable and can lead to treatment failure (C _min < 0.5 mg/L) and toxicity (C _min ≥ 5.0 mg/L). However, It remains challenging to determine the ideal maintenance dose to achieve the desired C _min level quickly.

Aims

This randomized, prospective observational single-center study aimed to identify factors affecting VCZ-C _min and maintenance dose and create an algorithmic model to predict the necessary maintenance dose. MeThe study enrolled 306 adult IFI patients, split into two groups: non-gene-directed (A) (where CYP2C19 phenotype is not involve

SUBMITTER: Zhou L 

PROVIDER: S-EPMC10410275 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature