Distinctive features of the central synaptic organization of Drosophila larval proprioceptors.

ABSTRACT: Proprioceptive feedback is critically needed for locomotor control, but how this information is incorporated into central proprioceptive processing circuits remains poorly understood. Circuit organization emerges from the spatial distribution of synaptic connections between neurons. This distribution is difficult to discern in model systems where only a few cells can be probed simultaneously. Therefore, we turned to a relatively simple and accessible nervous system to ask: how are proprioceptors' input and output synapses organized in space, and what principles underlie this organization? Using the Drosophila larval connectome, we generated a map of the input and output synapses of 34 proprioceptors in several adjacent body segments (5-6 left-right pairs per segment). We characteriz

SUBMITTER: Greaney MR 

PROVIDER: S-EPMC10410283 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature