Adult-onset leukodystrophies: a practical guide, recent treatment updates, and future directions.

ABSTRACT: Adult-onset leukodystrophies though individually rare are not uncommon. This group includes several disorders with isolated adult presentations, as well as several childhood leukodystrophies with attenuated phenotypes that present at a later age. Misdiagnoses often occur due to the clinical and radiological overlap with common acquired disorders such as infectious, immune, inflammatory, vascular, metabolic, and toxic etiologies. Increased prevalence of non-specific white matter changes in adult population poses challenges during diagnostic considerations. Clinico-radiological spectrum and molecular landscape of adult-onset leukodystrophies have not been completely elucidated at this time. Diagnostic approach is less well-standardized when compared to the childhood counterpart. Absence of f

SUBMITTER: Muthusamy K 

PROVIDER: S-EPMC10410460 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature