Structure and function of a dual antagonist of the human growth hormone and prolactin receptors with site-specific PEG conjugates.

ABSTRACT: Human growth hormone (hGH) is a pituitary-derived endocrine protein that regulates several critical postnatal physiologic processes including growth, organ development, and metabolism. Following adulthood, GH is also a regulator of multiple pathologies like fibrosis, cancer, and diabetes. Therefore, there is a significant pharmaceutical interest in developing antagonists of hGH action. Currently, there is a single FDA-approved antagonist of the hGH receptor (hGHR) prescribed for treating patients with acromegaly and discovered in our laboratory almost 3 decades ago. Here, we present the first data on the structure and function of a new set of protein antagonists with the full range of hGH actions-dual antagonists of hGH binding to the GHR as well as that of hGH binding to the prolactin rec

SUBMITTER: Basu R 

PROVIDER: S-EPMC10410519 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature