Impact of polymer chemistry on critical quality attributes of selective laser sintering 3D printed solid oral dosage forms.

ABSTRACT: The aim of this study is to investigate the influence of polymer chemistry on the properties of oral dosage forms produced using selective laser sintering (SLS). The dosage forms were printed using different grades of polyvinyl alcohol or copovidone in combination with indomethacin as the active pharmaceutical ingredient. The properties of the printed structures were assessed according to European Pharmacopoeia guidelines at different printing temperatures and laser scanning speeds in order to determine the suitable printing parameters. The results of the study indicate that the chemical properties of the polymers, such as dynamic viscosity, degree of hydrolyzation, and molecular weight, have significant impact on drug release and kinetics. Drug release rate and supersaturation can be modu

SUBMITTER: Evgenii T 

PROVIDER: S-EPMC10410523 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature