Adding Diversity to a Diruthenium Biscyclopentadienyl Scaffold via Alkyne Incorporation: Synthesis and Biological Studies.

ABSTRACT: We report the synthesis and the assessment of the anticancer potential of two series of diruthenium biscyclopentadienyl carbonyl complexes. Novel dimetallacyclopentenone compounds (2-4) were obtained (45-92% yields) from the thermal reaction (PhCCPh exchange) of [Ru₂Cp₂(CO)(μ-CO){μ-η¹:η³-C(Ph)═C(Ph)C(═O)}], 1, with alkynes HCCR [R = C₅H₄FeCp (Fc), 3-C₆H₄(Asp), 2-naphthyl; Cp = η⁵-C₅H₅, Asp = OC(O)-2-C₆H₄C(O)Me]. Protonation of 1-3 by HBF₄ afforded the corresponding μ-alkenyl derivatives 5-7, in 40-86% yields. All products were characterized by IR and NMR spectroscopy; moreover, cyclic volta

SUBMITTER: Bresciani G 

PROVIDER: S-EPMC10410612 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature