Networks Underlie Temporal Onset of Dysplasia-Related Epilepsy: A MELD Study.

ABSTRACT:

Objective

The purpose of this study was to evaluate if focal cortical dysplasia (FCD) co-localization to cortical functional networks is associated with the temporal distribution of epilepsy onset in FCD.

Methods

International (20 center), retrospective cohort from the Multi-Centre Epilepsy Lesion Detection (MELD) project. Patients included if >3 years old, had 3D pre-operative T1 magnetic resonance imaging (MRI; 1.5 or 3 T) with radiologic or histopathologic FCD after surgery. Images processed using the MELD protocol, masked with 3D regions-of-interest (ROI), and co-registered to fsaverage_sym (symmetric template). FCDs were then co-localized to 1 of 7 distributed functional cortical networks. Negative binomial regression evaluated effect of FCD size, network, histology, an

SUBMITTER: Cohen NT 

PROVIDER: S-EPMC10410674 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature