Fibers in smaller fascicles have lower activation thresholds with cuff electrodes due to thinner perineurium and smaller cross-sectional area.

ABSTRACT: Objective. In nerve stimulation therapies, fibers in larger fascicles generally have higher activation thresholds, but the mechanisms are not well understood. We implemented and analyzed computational models to uncover the effects of morphological parameters on activation thresholds.Approach. We implemented finite element models of human vagus nerve stimulation to quantify the effects of morphological parameters on thresholds in realistic nerves. We also implemented simplified models to isolate effects of perineurium thickness, endoneurium diameter, fiber diameter, and fascicle location on current density, potential distributions (V_e), and activation thresholds across cuff geometries and stimulation waveforms. UsingV_efrom each finite elemen

SUBMITTER: Davis CJ 

PROVIDER: S-EPMC10410695 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature