Mitochondrial sulfide promotes life span and health span through distinct mechanisms in developing versus adult treated Caenorhabditis elegans.

ABSTRACT: Living longer without simultaneously extending years spent in good health ("health span") is an increasing societal burden, demanding new therapeutic strategies. Hydrogen sulfide (H₂S) can correct disease-related mitochondrial metabolic deficiencies, and supraphysiological H₂S concentrations can pro health span. However, the efficacy and mechanisms of mitochondrion-targeted sulfide delivery molecules (mtH₂S) administered across the adult life course are unknown. Using a Caenorhabditis elegans aging model, we compared untargeted H₂S (NaGYY4137, 100 µM and 100 nM) and mtH₂S (AP39, 100 nM) donor effects on life span, neuromuscular health span, and mitochondrial integrity. H₂S donors were administered from birth or in you

SUBMITTER: Vintila AR 

PROVIDER: S-EPMC10410709 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature