GABAergic miR-34a regulates Dorsal Raphe inhibitory transmission in response to aversive, but not rewarding, stimuli.

ABSTRACT: The brain employs distinct circuitries to encode positive and negative valence stimuli, and dysfunctions of these neuronal circuits have a key role in the etiopathogenesis of many psychiatric disorders. The Dorsal Raphè Nucleus (DRN) is involved in various behaviors and drives the emotional response to rewarding and aversive experiences. Whether specific subpopulations of neurons within the DRN encode these behaviors with different valence is still unknown. Notably, microRNA expression in the mammalian brain is characterized by tissue and neuronal specificity, suggesting that it might play a role in cell and circuit functionality. However, this specificity has not been fully exploited. Here, we demonstrate that microRNA-34a (miR-34a) is selectively expressed in a subpopulation of GABAergic

SUBMITTER: Ielpo D 

PROVIDER: S-EPMC10410731 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature