Air pollution, genetic susceptibility, and the risk of atrial fibrillation: A large prospective cohort study.

ABSTRACT: To date, no study has explored the extent to which genetic susceptibility modifies the effects of air pollutants on the risk of atrial fibrillation (AF). This study was designed to investigate the separate and joint effects of long-term exposure to air pollutants and genetic susceptibility on the risk of AF events. This study included 401,251 participants without AF at baseline from UK Biobank. We constructed a polygenic risk score and categorized it into three categories. Cox proportional hazards models were fitted to assess the separate and joint effects of long-term exposure to air pollutants and genetics on the risk of AF. Additionally, we further evaluated the effect modification of genetic susceptibility. The hazard ratios and corresponding 95% confidence intervals of incident AF for

SUBMITTER: Ma Y 

PROVIDER: S-EPMC10410743 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature