Electrospun core-sheath PCL nanofibers loaded with nHA and simvastatin and their potential bone regeneration applications.

ABSTRACT: Introduction: Drugs and biocompatible nanoparticles have raised significant potential in advancing the bone regeneration. Electrospinning technology enables the full realization of the value of drugs and nanoparticles. Methods: In this study, we have successfully fabricated core-sheath nanofibers solely composed of polycaprolactone (PCL) polymer. Simvastatin (SIM) was confined to the core of the nanofibers while nanohydroxyapatite (nHA) was loaded on the nanofiber surface. Results: All the prepared nanofibers exhibited a cylindrical micromorphology, and the core-sheath structure was exploited using a Transmission Electron Microscope. X-ray pattern results indicated that SIM was in an amorphous state within nanofibers, while Fourier Transform InfraRed spectroscopy showe

SUBMITTER: Qian C 

PROVIDER: S-EPMC10410860 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature